The end of April is the annual-report deadline. By then — Hong Kong-listed companies aside, where quarterlies are not mandatory — many A-share players have already published Q1 as well.
Every set of annual-report numbers can be read from more than one angle. I rarely take any single company’s own reading at face value; I would much rather put companies in the same category side by side, because that is what carries weight. A head-to-head is what lets you see how different companies perform and behave in the same conditions, and pick up the signals that carry a long way but have not yet broken the surface.
This one runs long and carries a lot of numbers. Save it and take your time if the subject interests you.
Now that the industry has moved into a fight over a fixed pool, neither a rise nor a fall is a single story any more. Selling expense ratio, recurring net profit, gross margin, accounts receivable, goodwill impairment — read those five together and most of the startling numbers become calm.
Scope: twelve companies (7 A-share + 4 Hong Kong + 1 Beijing Stock Exchange), covering FY2025 annual reports and Q1 2026 figures disclosed as of 28 April 2026.
The twelve, and what they have disclosed
Companies were selected on the test of having medical-aesthetics products in development, production or sale, with results already comparable.
| Ticker | Company | Market | Core medical-aesthetics business | FY2025 report |
|---|---|---|---|---|
| 688363.SH | Bloomage Biotech | A-share · STAR Market | HA raw material + finished products + skincare | Disclosed |
| 300896.SZ | Imeik | A-share · ChiNext | HA injectables, CureWhite PLLA, Hearty | Disclosed |
| 000963.SZ | Huadong Medicine | A-share · Shenzhen Main Board | Ellanse PCL filler, MaiLi HA, Retoxin botulinum toxin | Disclosed |
| 688366.SH | Haohai Biological | A-share · STAR Market | HA fillers, intraocular lenses, RF and laser devices | Disclosed |
| 920982.BJ | Jinbo Biological (formerly 832982) | Beijing Stock Exchange | Leader in recombinant humanised type III collagen | Disclosed |
| 02367.HK | Giant Biogene | Hong Kong | Recombinant collagen; Comfy + Collgene | Disclosed |
| 02487.HK | Cutia Therapeutics-B | Hong Kong | Dermatology platform: fat management, hair, topical anaesthetic, botulinum toxin (Korea) | Disclosed |
| 00460.HK | Sihuan Pharmaceutical | Hong Kong | Full coverage: Letybo toxin, PLLA, PCL, hyaluronic acid | Disclosed |
| 00867.HK | China Medical System | Hong Kong | PLLA distribution, ECM implant; planned spin-off of Dermavon | Disclosed |
| 600196.SH | Fosun Pharma | A-share · Shanghai Main Board | Sisram energy-based devices (light and RF platform) | Disclosed |
| 300003.SZ | Lepu Medical | A-share · ChiNext | PLLA filler (the seventh certificate issued in China) | Disclosed |
| 600223.SH | Freda | A-share · Shanghai Main Board | HA raw material; Yilian + Dr. Alva + Kemi | Disclosed |
One comparable database (FY2025)
Unit: RMB 100 million
| Company | Revenue (RMB 100m) / YoY | Net profit attributable (RMB 100m) / YoY | Recurring net profit / YoY | Selling expense move | Gross margin | Medical aesthetics as % of revenue | Medical-aesthetics segment YoY |
|---|---|---|---|---|---|---|---|
| Bloomage Biotech | 41.99 / -21.82% | 2.92 / +67.59% | — | Selling expense -38.52% (ratio cut to 34.26%, a five-year low) | 70.33% | Diversified; medical aesthetics and skincare reported separately | Dermatology business in an adjustment cycle |
| Imeik | ~24.5 / ~-19% | ~12.9 / ~-34% | 10.99 / -41.30% | Q1 selling expense +67.3% (RMB 65.4m to RMB 109m) | 92.7% | 100% | Hearty loses momentum; a fight over a fixed pool |
| Huadong Medicine | 436.12 / +4.07% | 34.14 / — | 33.11 / -1.2% | Industrial segment +7.04% | ~33% (group level) | Medical aesthetics / Industrial Division I | Innovation revenue +64.2% |
| Haohai Biological | 24.73 / -8.33% | 2.51 / -40.30% | 1.60 / -57.67% | Goodwill impairment swallows the profit | 70.1% | ~42% | Medical aesthetics -12.99%; hyaluronic acid -23.27% |
| Jinbo Biological | 15.95 / +10.6% | 6.52 / -11.0% | — | Selling expense ratio rising | ~91% | 100% | Down from a doubling to double digits |
| Giant Biogene | 55.19 / -0.4% | 19.15 / -7.2% | — | Selling expense ratio 37.3% | 80.3% | 100% | Comfy -1.6% (DTC -20% in H2) |
| Cutia Therapeutics-B | 3.36 / +20.2% | -3.40 / Loss narrowed 21.6% | Adjusted loss RMB 314m | Selling and distribution expense -17.2% | 58.0% | 100% | Commercialised products keep scaling |
| Sihuan Pharmaceutical | 26.18 / +37.7% | 1.85 / Returned to profit | — | Deliberately shrinking generics -13% | 68.8% | 57% (first time above 50%) | Medical aesthetics RMB 1.485bn, roughly +100% |
| China Medical System | 82.1 / +9.9% | 14.4 / -10.5%* | — | — | 71.5% | Includes dermatological aesthetics | Skin health line (including Demei) revenue RMB 1.07bn, +73.2% |
| Fosun Pharma | 416.62 / +1.45% | 33.71 / +21.69% | 23.40 / +1.12% | Innovative drugs +29.59% | ~50% | Sisram | Direct sales up to 78% of the mix |
| Lepu Medical | 64.83 / +6.22% | 9.62 / +289.57%(low base) | — | RMB 250m of goodwill impairment cleared in 2024 | ~67% | Devices / pharmaceuticals | PLLA filler approved June 2025 |
| Freda | 36.51 / -8.33% | 1.88 / -22.9% | — | — | 51.5% | Cosmetics RMB 2.246bn | Kemi growing fast; Yilian +8.26% |
Gross margin ranking: the most direct measure of pricing power
The pure medical-aesthetics names (Imeik, Jinbo) run gross margins above 90% — on paper, Moutai territory. The diversified pharma groups are pulled down by low-margin distribution, but their medical-aesthetics segments are typically above 70%.
FY2025 gross margin ranking (12 companies)
Different narratives behind the same numbers
Case A:Bloomage vs Imeik — the same revenue decline, opposite strategies
This pairing needs two time windows read together: full-year 2025 and Q1 2026. Either one on its own shows you only half the story.
| Metric | FY2025 | 2026 Q1 | ||
|---|---|---|---|---|
| Bloomage Biotech | Imeik | Bloomage Biotech | Imeik | |
| Revenue growth | -21.82% | ~-19% | -20.77% | -4.48% |
| Selling expense | -38.52% | — | — | +67.3% |
| Selling expense ratio | 34.26% (five-year low) | — | — | Up sharply |
| Net profit attributable | +67.59% | ~-34% | -58.13% | -32.79% |
Bloomage cut nearly 40% of its selling expense in 2025 and net profit rebounded 67%. But Q1 revenue kept falling, down 20%, and net profit collapsed 58% — which says that a profit rebound bought with cost control does not carry.
Imeik saw both revenue and profit fall across 2025, then in Q1 revenue was down less than 5% while selling expense went from RMB 65.4m to RMB 109m (+67.3%). It is spending profit to defend share.
Bloomage is betting on contract first, then turn. Imeik is betting on spending more to hold share.
And it is not only Imeik. Jinbo Biological, top of the table on net margin, raised H1 2025 selling expense 67.77% (almost exactly Imeik’s Q1 +67.3%), and Giant Biogene’s full-year selling expense ratio rose to 37.3%. Hyaluronic acid (Imeik), recombinant collagen (Giant Biogene), recombinant type III collagen (Jinbo): the leading product companies have moved as a group into spend-more-to-defend-share mode. Slightly different categories, identical behaviour. Where those three take their selling expense ratios over the rest of this year matters more than the net profit figures themselves.
Case B:Lepu Medical — turnaround? rebound? or just repetition?
| Reporting period | Net profit attributable | YoY | How the press framed it |
|---|---|---|---|
| FY2023 | RMB 1.26bn | — | Solid |
| FY2024 | RMB 247m | -80.37% | “Worst in the sixteen years since listing” |
| FY2025 report | RMB 962m | +289.57% | “Volume-based procurement cleared; turnaround confirmed” |
| 2026 Q1 | RMB 247m | -34.8% | “Results turn down again” |
The RMB 250m goodwill impairment taken in 2024 drove the base to the floor; 2025 net profit rebounded to RMB 962m, +290% year on year, which looks handsome. But one quarter later Q1 was down 34.8% again, and RMB 3.879bn of goodwill is still hanging there. +290% is a rebound, not a turn in the story.
The PLLA approval in June 2025 is genuinely good news, but the real pace of sales cannot be verified until the middle of 2026. Welding a newly approved product to a low-base rebound and calling it a confirmed turnaround is two separate things forced together.
Remember the story six months ago about sales passing RMB 100m in three months?
RMB 100m including tax converts back to roughly RMB 88.5m excluding it — the same money as the RMB 86m in the financial statements. The number is broadly true. The definition was carefully chosen. On the strict basis used in the accounts, it had not passed RMB 100m as of 30 September.
But more interesting than the made-up definition is another set of hard numbers Lepu disclosed in its own 2025 annual report, which cannot be dressed up:
| Metric | 2023 | 2024 | 2025 | Trend |
|---|---|---|---|---|
| Accounts receivable / revenue | 21.97% | 25.08% | 30.67% | Three consecutive years of increase; up 5.59 points in 2025 alone |
| Receivables turnover (times) | 4.36 | 3.72 | 3.68 | Collection efficiency keeps deteriorating |
| Accounts receivable / net profit attributable | — | — | 232.94% | About RMB 2.24bn of receivables on the books, 2.3 times net profit |
Put those three together and the truth about channel-loading sales is exposed: group revenue in 2025 rose only 6.22%, yet receivables as a share of revenue jumped 5.59 points in a single year — the growth in new receivables far outpaced the growth in new revenue, and the gap most likely came from loading the new product into the channel.
If collections on the new product were normal, the receivables ratio would not be setting a record at the same time.
I am looking forward to the breakdown of medical-aesthetics receivables and repeat-purchase rates in the 2026 annual report.
Valuation: two groups of names in a PE-ROE frame
Read PE and ROE together and it becomes obvious which names are expensive for a reason and which are expensive with nothing underneath.
Valuation trough (low PE + solid fundamentals)
| Company | PE | ROE | Assessment |
|---|---|---|---|
| China Medical System | ~12x | ~18% | Undervalued, with a spin-off catalyst |
| Fosun Pharma | ~16x | ~10% | Reasonable, slightly low |
| Huadong Medicine | ~20x | ~16% | Reasonable + products delivering |
| Lepu Medical | ~25x | ~12% | Reasonable, but goodwill overhead |
Rich valuation (needs high growth to support it)
| Company | PE | ROE | Assessment |
|---|---|---|---|
| Jinbo Biological | ~55x | Declining; on a like-for-like H1 basis 28.51% to 23.01%, -5.50pt | ROE declining |
| Imeik | ~55x | ~20% | Slowing growth deserves caution |
| Sihuan Pharmaceutical | ~55x | ~11% | Durability of medical-aesthetics margins still unproven |
| Giant Biogene | ~38x | ~28% | The selling expense ratio signal needs watching |
| Haohai Biological | ~65x | ~4% | Rich valuation + deteriorating results |
| Bloomage Biotech | ~90x | ~4% | Severe PE-ROE mismatch |
Financial health and anomaly detection
These measures show the real state of things better than a year-on-year profit figure.
| Company | Gearing | Operating cash flow / net profit | Financial health | Warning signs |
|---|---|---|---|---|
| Imeik | ~15% | >100% | Strong | The Q1 selling expense ratio inflection is well supported |
| Jinbo Biological | ~20% | ~90% | Strong | Receivables growing fast |
| Giant Biogene | ~12% | >100% | Strong | Revenue negative for the first time |
| China Medical System | ~30% | >90% | Good | Spin-off listing creates one-off gains and losses |
| Huadong Medicine | ~55% | ~80% | Good | Gearing on the high side (includes distribution business) |
| Haohai Biological | ~25% | ~70% | Good | Goodwill impairment; recurring net profit -57.67% |
| Fosun Pharma | ~60% | ~60% | Average | Large goodwill balance, high gearing |
| Sihuan Pharmaceutical | ~56% | Returned to profit | Improving | Generics deliberately reduced -13% |
| Lepu Medical | ~45% | ~70% | Improving | RMB 3.879bn of goodwill overhead |
| Bloomage Biotech | ~30% | <50% | Caution | Revenue falling, transition unclear, profit propped up by cost control |
| Freda | ~51% | Improving | Average | Dr. Alva’s adjustment period is a drag |
| Cutia Therapeutics-B | ~32% | Negative | High risk | Sustained losses, burning cash |
Shareholder structure and where the money leans
State backing, institutional ownership, Hong Kong small caps — the logic driving the share price is completely different in each case.
| Company | Controlling shareholder / ownership type | Major shareholder stake | Institutional ownership profile | Where the money leans |
|---|---|---|---|---|
| Imeik | Private (Jian Jun) | ~48% | Heavily held by mutual funds | Favoured by northbound flows |
| Bloomage Biotech | Private (Zhao Yan) | ~36% | Institutional ownership down sharply | Persistent outflows |
| Haohai Biological | Private | ~25% | Relatively dispersed | Thin liquidity (turnover only 0.2-0.3%) |
| Huadong Medicine | State-owned (Huadong Medicine Group) | ~35% | Mutual funds + social security funds | Core institutional holding |
| Jinbo Biological | Private (Yang Xia) | ~45% | A scarce name on the Beijing Stock Exchange | Concentrated inflows in 2024; unclear after the 2025 profit decline |
| Giant Biogene | Private (Fan Daidi) | ~60% | Stock Connect eligible | Held via southbound flows |
| Sihuan Pharmaceutical | Private | ~50% | Hong Kong small cap, low institutional ownership | Mostly speculative money |
| Cutia Therapeutics-B | Private + Sequoia ~12% | ~35% | Mainly PE / VC | Liquidity under pressure since removal from Stock Connect; PE/VC holdings have limited liquidity |
| China Medical System | Private (Lin Gang) | ~40% | Long-term value holders | A low valuation attracts value money |
| Fosun Pharma | Private (Fosun Group / Guo Guangchang) | ~37% | Dual-listed A+H, held by institutions | Neutral to cautious (large group goodwill + overall debt + liquidity transmission risk) |
| Lepu Medical | Private | ~28% | Relatively dispersed | Retail speculators and thematic money (turnover 5-9%, a regular on the daily most-active list) |
| Freda | State-owned (Shandong Commercial Group) | ~46% | A local state-reform name | State capital + cosmetics-transition thematic money |
Weighted five-dimension score
Weighted across five dimensions: profitability (25%), growth (25%), valuation (20%), financial health (15%), shareholder structure (15%). The weights are Giselle’s own, set as the author, and are offered for reference only.
| Company | Profitability | Growth | Valuation | Financials | Shareholders | Overall | View |
|---|---|---|---|---|---|---|---|
| China Medical System | 78 | 72 | 92 | 85 | 82 | 82 | Favoured |
| Huadong Medicine | 72 | 82 | 85 | 72 | 85 | 79 | Favoured |
| Jinbo Biological | 85 | 65 | 55 | 88 | 78 | 73 | Wait for the valuation to digest |
| Imeik | 85 | 38 | 62 | 95 | 85 | 70 | Neutral to cautious |
| Sihuan Pharmaceutical | 62 | 88 | 60 | 68 | 58 | 68 | Watch |
| Giant Biogene | 75 | 35 | 68 | 92 | 80 | 67 | Watch |
| Fosun Pharma | 62 | 58 | 78 | 55 | 70 | 64 | Neutral |
| Lepu Medical | 65 | 55 | 72 | 62 | 62 | 63 | Neutral |
| Haohai Biological | 58 | 38 | 55 | 65 | 62 | 55 | Watch |
| Freda | 48 | 50 | 55 | 52 | 62 | 53 | Watch |
| Cutia Therapeutics-B | 25 | 75 | 50 | 32 | 50 | 47 | High risk |
| Bloomage Biotech | 28 | 22 | 22 | 42 | 50 | 32 | Avoid / wait for the turn |
What Q1 2026 disclosures already show
A quick look at the core A-share names that had disclosed Q1 as of 28 April 2026. A single quarter should not be over-read; use it for directional signals.
| Company | Q1 revenue (RMB 100m) / YoY | Q1 net profit attributable (RMB 100m) / YoY | Key signal |
|---|---|---|---|
| Bloomage Biotech | 10.78 / -20.77% | 1.02 / -58.13% | The profit rebound bought by cutting marketing did not carry; the adjustment cycle continues |
| Imeik | 6.34 / -4.48% | 2.98 / -32.79% | Selling expense +67%, spending more to hold share |
| Huadong Medicine | 111.83 / +4.17% | Recurring 9.90 / +10.30% | Record quarterly recurring net profit; PCL filler and toxin both acting as catalysts |
| Haohai Biological | 5.71 / -7.62% | 0.74 / -18.55% | Recurring net profit -34.3%; hyaluronic acid still under pressure |
| Lepu Medical | 16.72 / -3.7% | 2.47 / -34.8% | The +290% rebound in the annual report did not carry |
Sources: each company’s FY2025 annual report, results announcements, profit alerts and Q1 2026 report; Cutia Therapeutics-B FY2025 results announcement (24 March 2026); Cutia Therapeutics-B FY2025 annual report (24 April 2026); Jinbo Biological FY2025 annual report (29 April 2026).

