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Upstream Medical Aesthetics, FY2025: A Head-to-Head Review of 12 Listed Companies

The end of April is the annual-report deadline. By then — Hong Kong-listed companies aside, where quarterlies are not mandatory — many A-share players have already published Q1 as well.

By Giselle 3,076 words 14 min read
28
April
2026

The end of April is the annual-report deadline. By then — Hong Kong-listed companies aside, where quarterlies are not mandatory — many A-share players have already published Q1 as well.

Every set of annual-report numbers can be read from more than one angle. I rarely take any single company’s own reading at face value; I would much rather put companies in the same category side by side, because that is what carries weight. A head-to-head is what lets you see how different companies perform and behave in the same conditions, and pick up the signals that carry a long way but have not yet broken the surface.

This one runs long and carries a lot of numbers. Save it and take your time if the subject interests you.

Now that the industry has moved into a fight over a fixed pool, neither a rise nor a fall is a single story any more. Selling expense ratio, recurring net profit, gross margin, accounts receivable, goodwill impairment — read those five together and most of the startling numbers become calm.

Scope: twelve companies (7 A-share + 4 Hong Kong + 1 Beijing Stock Exchange), covering FY2025 annual reports and Q1 2026 figures disclosed as of 28 April 2026.

01

The twelve, and what they have disclosed

Companies were selected on the test of having medical-aesthetics products in development, production or sale, with results already comparable.

TickerCompanyMarketCore medical-aesthetics businessFY2025 report
688363.SHBloomage BiotechA-share · STAR MarketHA raw material + finished products + skincareDisclosed
300896.SZImeikA-share · ChiNextHA injectables, CureWhite PLLA, HeartyDisclosed
000963.SZHuadong MedicineA-share · Shenzhen Main BoardEllanse PCL filler, MaiLi HA, Retoxin botulinum toxinDisclosed
688366.SHHaohai BiologicalA-share · STAR MarketHA fillers, intraocular lenses, RF and laser devicesDisclosed
920982.BJJinbo Biological (formerly 832982)Beijing Stock ExchangeLeader in recombinant humanised type III collagenDisclosed
02367.HKGiant BiogeneHong KongRecombinant collagen; Comfy + CollgeneDisclosed
02487.HKCutia Therapeutics-BHong KongDermatology platform: fat management, hair, topical anaesthetic, botulinum toxin (Korea)Disclosed
00460.HKSihuan PharmaceuticalHong KongFull coverage: Letybo toxin, PLLA, PCL, hyaluronic acidDisclosed
00867.HKChina Medical SystemHong KongPLLA distribution, ECM implant; planned spin-off of DermavonDisclosed
600196.SHFosun PharmaA-share · Shanghai Main BoardSisram energy-based devices (light and RF platform)Disclosed
300003.SZLepu MedicalA-share · ChiNextPLLA filler (the seventh certificate issued in China)Disclosed
600223.SHFredaA-share · Shanghai Main BoardHA raw material; Yilian + Dr. Alva + KemiDisclosed
02

One comparable database (FY2025)

Unit: RMB 100 million

CompanyRevenue (RMB 100m) / YoYNet profit attributable (RMB 100m) / YoYRecurring net profit / YoYSelling expense moveGross marginMedical aesthetics as % of revenueMedical-aesthetics segment YoY
Bloomage Biotech41.99 / -21.82%2.92 / +67.59%—Selling expense -38.52% (ratio cut to 34.26%, a five-year low)70.33%Diversified; medical aesthetics and skincare reported separatelyDermatology business in an adjustment cycle
Imeik~24.5 / ~-19%~12.9 / ~-34%10.99 / -41.30%Q1 selling expense +67.3% (RMB 65.4m to RMB 109m)92.7%100%Hearty loses momentum; a fight over a fixed pool
Huadong Medicine436.12 / +4.07%34.14 / —33.11 / -1.2%Industrial segment +7.04%~33% (group level)Medical aesthetics / Industrial Division IInnovation revenue +64.2%
Haohai Biological24.73 / -8.33%2.51 / -40.30%1.60 / -57.67%Goodwill impairment swallows the profit70.1%~42%Medical aesthetics -12.99%; hyaluronic acid -23.27%
Jinbo Biological15.95 / +10.6%6.52 / -11.0%—Selling expense ratio rising~91%100%Down from a doubling to double digits
Giant Biogene55.19 / -0.4%19.15 / -7.2%—Selling expense ratio 37.3%80.3%100%Comfy -1.6% (DTC -20% in H2)
Cutia Therapeutics-B3.36 / +20.2%-3.40 / Loss narrowed 21.6%Adjusted loss RMB 314mSelling and distribution expense -17.2%58.0%100%Commercialised products keep scaling
Sihuan Pharmaceutical26.18 / +37.7%1.85 / Returned to profit—Deliberately shrinking generics -13%68.8%57% (first time above 50%)Medical aesthetics RMB 1.485bn, roughly +100%
China Medical System82.1 / +9.9%14.4 / -10.5%*——71.5%Includes dermatological aestheticsSkin health line (including Demei) revenue RMB 1.07bn, +73.2%
Fosun Pharma416.62 / +1.45%33.71 / +21.69%23.40 / +1.12%Innovative drugs +29.59%~50%SisramDirect sales up to 78% of the mix
Lepu Medical64.83 / +6.22%9.62 / +289.57%(low base)—RMB 250m of goodwill impairment cleared in 2024~67%Devices / pharmaceuticalsPLLA filler approved June 2025
Freda36.51 / -8.33%1.88 / -22.9%——51.5%Cosmetics RMB 2.246bnKemi growing fast; Yilian +8.26%
03

Gross margin ranking: the most direct measure of pricing power

The pure medical-aesthetics names (Imeik, Jinbo) run gross margins above 90% — on paper, Moutai territory. The diversified pharma groups are pulled down by low-margin distribution, but their medical-aesthetics segments are typically above 70%.

04

Different narratives behind the same numbers

Case A:Bloomage vs Imeik — the same revenue decline, opposite strategies

This pairing needs two time windows read together: full-year 2025 and Q1 2026. Either one on its own shows you only half the story.

MetricFY20252026 Q1
Bloomage BiotechImeikBloomage BiotechImeik
Revenue growth-21.82%~-19%-20.77%-4.48%
Selling expense-38.52%——+67.3%
Selling expense ratio34.26% (five-year low)——Up sharply
Net profit attributable+67.59%~-34%-58.13%-32.79%

Bloomage cut nearly 40% of its selling expense in 2025 and net profit rebounded 67%. But Q1 revenue kept falling, down 20%, and net profit collapsed 58% — which says that a profit rebound bought with cost control does not carry.

Imeik saw both revenue and profit fall across 2025, then in Q1 revenue was down less than 5% while selling expense went from RMB 65.4m to RMB 109m (+67.3%). It is spending profit to defend share.

Bloomage is betting on contract first, then turn. Imeik is betting on spending more to hold share.

And it is not only Imeik. Jinbo Biological, top of the table on net margin, raised H1 2025 selling expense 67.77% (almost exactly Imeik’s Q1 +67.3%), and Giant Biogene’s full-year selling expense ratio rose to 37.3%. Hyaluronic acid (Imeik), recombinant collagen (Giant Biogene), recombinant type III collagen (Jinbo): the leading product companies have moved as a group into spend-more-to-defend-share mode. Slightly different categories, identical behaviour. Where those three take their selling expense ratios over the rest of this year matters more than the net profit figures themselves.

Case B:Lepu Medical — turnaround? rebound? or just repetition?

Reporting periodNet profit attributableYoYHow the press framed it
FY2023RMB 1.26bn—Solid
FY2024RMB 247m-80.37%“Worst in the sixteen years since listing”
FY2025 reportRMB 962m+289.57%“Volume-based procurement cleared; turnaround confirmed”
2026 Q1RMB 247m-34.8%“Results turn down again”

The RMB 250m goodwill impairment taken in 2024 drove the base to the floor; 2025 net profit rebounded to RMB 962m, +290% year on year, which looks handsome. But one quarter later Q1 was down 34.8% again, and RMB 3.879bn of goodwill is still hanging there. +290% is a rebound, not a turn in the story.

The PLLA approval in June 2025 is genuinely good news, but the real pace of sales cannot be verified until the middle of 2026. Welding a newly approved product to a low-base rebound and calling it a confirmed turnaround is two separate things forced together.

Remember the story six months ago about sales passing RMB 100m in three months?

RMB 100m including tax converts back to roughly RMB 88.5m excluding it — the same money as the RMB 86m in the financial statements. The number is broadly true. The definition was carefully chosen. On the strict basis used in the accounts, it had not passed RMB 100m as of 30 September.

But more interesting than the made-up definition is another set of hard numbers Lepu disclosed in its own 2025 annual report, which cannot be dressed up:

Metric202320242025Trend
Accounts receivable / revenue21.97%25.08%30.67%Three consecutive years of increase; up 5.59 points in 2025 alone
Receivables turnover (times)4.363.723.68Collection efficiency keeps deteriorating
Accounts receivable / net profit attributable——232.94%About RMB 2.24bn of receivables on the books, 2.3 times net profit

Put those three together and the truth about channel-loading sales is exposed: group revenue in 2025 rose only 6.22%, yet receivables as a share of revenue jumped 5.59 points in a single year — the growth in new receivables far outpaced the growth in new revenue, and the gap most likely came from loading the new product into the channel.

If collections on the new product were normal, the receivables ratio would not be setting a record at the same time.

I am looking forward to the breakdown of medical-aesthetics receivables and repeat-purchase rates in the 2026 annual report.

05

Valuation: two groups of names in a PE-ROE frame

Read PE and ROE together and it becomes obvious which names are expensive for a reason and which are expensive with nothing underneath.

Valuation trough (low PE + solid fundamentals)

CompanyPEROEAssessment
China Medical System~12x~18%Undervalued, with a spin-off catalyst
Fosun Pharma~16x~10%Reasonable, slightly low
Huadong Medicine~20x~16%Reasonable + products delivering
Lepu Medical~25x~12%Reasonable, but goodwill overhead

Rich valuation (needs high growth to support it)

CompanyPEROEAssessment
Jinbo Biological~55xDeclining; on a like-for-like H1 basis 28.51% to 23.01%, -5.50ptROE declining
Imeik~55x~20%Slowing growth deserves caution
Sihuan Pharmaceutical~55x~11%Durability of medical-aesthetics margins still unproven
Giant Biogene~38x~28%The selling expense ratio signal needs watching
Haohai Biological~65x~4%Rich valuation + deteriorating results
Bloomage Biotech~90x~4%Severe PE-ROE mismatch
06

Financial health and anomaly detection

These measures show the real state of things better than a year-on-year profit figure.

CompanyGearingOperating cash flow / net profitFinancial healthWarning signs
Imeik~15%>100%StrongThe Q1 selling expense ratio inflection is well supported
Jinbo Biological~20%~90%StrongReceivables growing fast
Giant Biogene~12%>100%StrongRevenue negative for the first time
China Medical System~30%>90%GoodSpin-off listing creates one-off gains and losses
Huadong Medicine~55%~80%GoodGearing on the high side (includes distribution business)
Haohai Biological~25%~70%GoodGoodwill impairment; recurring net profit -57.67%
Fosun Pharma~60%~60%AverageLarge goodwill balance, high gearing
Sihuan Pharmaceutical~56%Returned to profitImprovingGenerics deliberately reduced -13%
Lepu Medical~45%~70%ImprovingRMB 3.879bn of goodwill overhead
Bloomage Biotech~30%<50%CautionRevenue falling, transition unclear, profit propped up by cost control
Freda~51%ImprovingAverageDr. Alva’s adjustment period is a drag
Cutia Therapeutics-B~32%NegativeHigh riskSustained losses, burning cash
07

Shareholder structure and where the money leans

State backing, institutional ownership, Hong Kong small caps — the logic driving the share price is completely different in each case.

CompanyControlling shareholder / ownership typeMajor shareholder stakeInstitutional ownership profileWhere the money leans
ImeikPrivate (Jian Jun)~48%Heavily held by mutual fundsFavoured by northbound flows
Bloomage BiotechPrivate (Zhao Yan)~36%Institutional ownership down sharplyPersistent outflows
Haohai BiologicalPrivate~25%Relatively dispersedThin liquidity (turnover only 0.2-0.3%)
Huadong MedicineState-owned (Huadong Medicine Group)~35%Mutual funds + social security fundsCore institutional holding
Jinbo BiologicalPrivate (Yang Xia)~45%A scarce name on the Beijing Stock ExchangeConcentrated inflows in 2024; unclear after the 2025 profit decline
Giant BiogenePrivate (Fan Daidi)~60%Stock Connect eligibleHeld via southbound flows
Sihuan PharmaceuticalPrivate~50%Hong Kong small cap, low institutional ownershipMostly speculative money
Cutia Therapeutics-BPrivate + Sequoia ~12%~35%Mainly PE / VCLiquidity under pressure since removal from Stock Connect; PE/VC holdings have limited liquidity
China Medical SystemPrivate (Lin Gang)~40%Long-term value holdersA low valuation attracts value money
Fosun PharmaPrivate (Fosun Group / Guo Guangchang)~37%Dual-listed A+H, held by institutionsNeutral to cautious (large group goodwill + overall debt + liquidity transmission risk)
Lepu MedicalPrivate~28%Relatively dispersedRetail speculators and thematic money (turnover 5-9%, a regular on the daily most-active list)
FredaState-owned (Shandong Commercial Group)~46%A local state-reform nameState capital + cosmetics-transition thematic money
08

Weighted five-dimension score

Weighted across five dimensions: profitability (25%), growth (25%), valuation (20%), financial health (15%), shareholder structure (15%). The weights are Giselle’s own, set as the author, and are offered for reference only.

CompanyProfitabilityGrowthValuationFinancialsShareholdersOverallView
China Medical System787292858282Favoured
Huadong Medicine728285728579Favoured
Jinbo Biological856555887873Wait for the valuation to digest
Imeik853862958570Neutral to cautious
Sihuan Pharmaceutical628860685868Watch
Giant Biogene753568928067Watch
Fosun Pharma625878557064Neutral
Lepu Medical655572626263Neutral
Haohai Biological583855656255Watch
Freda485055526253Watch
Cutia Therapeutics-B257550325047High risk
Bloomage Biotech282222425032Avoid / wait for the turn
09

What Q1 2026 disclosures already show

A quick look at the core A-share names that had disclosed Q1 as of 28 April 2026. A single quarter should not be over-read; use it for directional signals.

CompanyQ1 revenue (RMB 100m) / YoYQ1 net profit attributable (RMB 100m) / YoYKey signal
Bloomage Biotech10.78 / -20.77%1.02 / -58.13%The profit rebound bought by cutting marketing did not carry; the adjustment cycle continues
Imeik6.34 / -4.48%2.98 / -32.79%Selling expense +67%, spending more to hold share
Huadong Medicine111.83 / +4.17%Recurring 9.90 / +10.30%Record quarterly recurring net profit; PCL filler and toxin both acting as catalysts
Haohai Biological5.71 / -7.62%0.74 / -18.55%Recurring net profit -34.3%; hyaluronic acid still under pressure
Lepu Medical16.72 / -3.7%2.47 / -34.8%The +290% rebound in the annual report did not carry

Sources: each company’s FY2025 annual report, results announcements, profit alerts and Q1 2026 report; Cutia Therapeutics-B FY2025 results announcement (24 March 2026); Cutia Therapeutics-B FY2025 annual report (24 April 2026); Jinbo Biological FY2025 annual report (29 April 2026).

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